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Specific tritium labelling of lysine‐vasopressin in two different aminoacid residues
Author(s) -
Kéri Gy.,
Teplán I.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580150120
Subject(s) - tritium , chemistry , labelling , vasopressin , peptide , lysine , tritium illumination , peptide synthesis , specific activity , chloramine t , radiochemistry , residue (chemistry) , chromatography , biochemistry , organic chemistry , amino acid , enzyme , medicine , physics , nuclear physics
Lysine 8 ‐vasopressin was specifically labelled with tritium in the tyrosine 2 and phenylalanine 3 residues. The 3, 5‐dibromo‐tyrosine 2 and 4‐chloro‐phenylalanine 3 derivatives of the hormone were synthesized by solid phase peptide synthesis. The halogen containing peptides were catalytically reduced by tritium gas yielding preparations with high specific radioactivity and full biological activity as compared with reference material.