Premium
Microscale synthesis of phosphorus trichloride labeled with high specific activity 33 p
Author(s) -
Woo D. V.,
Rupp A. F.,
Poggenburg J. K.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580150117
Subject(s) - chemistry , phosphorus trichloride , phosphorus , phosphate , phosphorus pentachloride , chlorine , phosphoric acid , inorganic chemistry , organic chemistry
Abstract Milligram quantities of high specific activity 33 P‐labeled phosphorus trichloride are synthesized from carrier‐free 33 P‐labeled phosphoric acid ( 33 P‐H 3 PO 4 ). Special apparatus were constructed for this synthesis. Carrierfree 33 P‐H 3 PO 4 is converted to lead phosphate in the presence of carrier by metathesis with lead oxide. Upon hydrogen reduction of the lead phosphate, elemental phosphorus is liberated and reacted with chlorine to form phosphorus pentachloride. Subsequent reduction in a specially constructed phosphorus reductor yields the phosphorus trichloride which is collected and sealed in an ampul. The procedures described are applicable to routine production of millicurie or multicurie quantities of several 33 P‐labeled phosphorus intermediates.