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Synthesis of potassium [ 14 C] dicloxacillin
Author(s) -
Ferdinandi E. S.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580140513
Subject(s) - chemistry , yield (engineering) , potassium , dicloxacillin , ring (chemistry) , stereochemistry , isoxazole , radiochemistry , medicinal chemistry , organic chemistry , penicillin , biochemistry , materials science , metallurgy , antibiotics
A synthesis of potassium [ 14 C] dicloxacillin, labelled in the 3‐position of the isoxazole ring, is described. The compound, having the specific activity 21 mCi/mmole, was obtained in 30% overall yield from ethyl [3‐ 14 C] acetoacetate.