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Labelled compounds of potential biological interest VI. Preparation of some labelled local anaesthetic aminoethers
Author(s) -
Gosztonyi Tamas,
Domeij Karl Erik,
Sandberg Rune
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580140502
Subject(s) - chemistry , butyrophenone , deuterium , local anaesthetic , tritium , radiochemistry , benzene , organic chemistry , nuclear chemistry , anesthesia , quantum mechanics , neuroscience , nuclear physics , dopamine , haloperidol , biology , medicine , physics
2′‐(2‐Diisopropylaminoethoxy)‐butyrophenone (ketocaine) and 1‐butoxy‐2‐(2‐diisopropylaminoethoxy)‐benzene show a good anaesthetic effect on topical application. The synthesis of both of these compounds specifically labelled with 14 C is described. The preparation of ketocaine generally labelled with tritium and specifically labelled with deuterium is also reported.