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Synthesis of 14 C‐labeled 2,4,2,′5′‐tetrachlorobiphenyl
Author(s) -
Moriya Takashi
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580140419
Subject(s) - chemistry , yield (engineering) , benzene , dichlorobenzene , stereochemistry , medicinal chemistry , organic chemistry , metallurgy , materials science
A synthetic procedure for 2,4,2,′5′‐tetrachlorobiphenyl‐1,2,3,4,5,6‐ 14 C 6 is presented. 2,4‐Dichloroaniline‐ 14 C 6 was prepared in 46.7% yield from benzene‐ 14 C 6 via m ‐dinitrobenzene‐ 14 C 6 , m ‐dichlorobenzene‐ 14 C 6 and 2,4‐dichloronitrobenzene‐ 14 C 6 . 2,4‐Dichloroaniline‐ 14 C 6 was coupled with p ‐dichlorobenzene to produce 14 C‐labeled tetrachlorobiphenyl. The yield was 21% based on 2,4‐dichloroaniline‐ 14 C 6 .