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A synthesis of 1‐(1‐ 14 C‐ethoxycarbonyl)‐2‐ethoxy‐1,2‐dihydroquinoline [ 14 C‐EEDQ]
Author(s) -
Robinson W. T.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580140408
Subject(s) - chemistry , ethanol , alkoxy group , phosgene , stereochemistry , organic chemistry , alkyl
A three step in situ micro synthesis is described for 1‐(1‐ 14 C‐ethoxycarbonyl)‐2‐ethoxy‐1, 2‐dihydroquinoline [ 14 C‐EEDQ]. Ethylchloroformate made from 1‐ 14 C‐ethanol and phosgene is allowed to react with quinoline and subsequently ethanol in the presence of Na 2 CO 3 to form 14 C‐EEDQ.