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A novel synthesis of maleic anhydride‐1‐ and ‐2‐ 13 C and its subsequent conversion to labeled maleic hydrazide
Author(s) -
Patterson John M.,
Braun Loren L.,
Haidar Nabeel F.,
Huang Jack C.,
Smith Walter T.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580140318
Subject(s) - chemistry , hydrazide , maleic anhydride , hydrazine (antidepressant) , aqueous solution , maleic acid , nitrogen , organic chemistry , sulfate , polymer chemistry , chromatography , copolymer , polymer
Maleic anhydride‐1‐ and 2‐ 13 C were synthesized respectively from the available aspartic acid‐4‐ and ‐3‐ 13 C by way of the corresponding bromosuccinic acids and their anhydrides. The maleic anhydrides were converted into 1,2‐dihydro‐3,6‐pyrida‐zinedione‐3‐ and ‐4‐ 13 C on treatment with aqueous hydrazine sulfate. Nitrogen‐15 labeled 1,2‐dihydro‐3,6‐pyridazinedione was obtained from the latter reaction using hydrazine‐ 15 N sulfate.