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High specific activity labelling of some tricyclic antidepressants
Author(s) -
Buchman O.,
PriBar I.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580140216
Subject(s) - tricyclic , desipramine , chemistry , imipramine , amitriptyline , labelling , catalysis , palladium , tritium , pharmacology , organic chemistry , medicine , biochemistry , antidepressant , physics , alternative medicine , pathology , hippocampus , nuclear physics
Activated palladium is used as catalyst for the hydrogen‐tritium exchange in tricyclic antidepressants. The specific activities obtained are: desipramine: 44.9 Ci/mmol; imipramine: 14.9 Ci/mmol; notriptyline: 2.0 Ci/mmol and amitriptyline: 1.7 Ci/mmol.