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Biosynthetic preparation of diethylstilbestrol monoglucuronide – (glucuronyl‐U‐ 14 C)
Author(s) -
Corbett M. D.,
Duncan W. P.,
Chipko B. R.,
Cahoy J. E.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580140203
Subject(s) - chemistry , diethylstilbestrol , uridine , yield (engineering) , microsome , specific activity , radiochemistry , glucuronic acid , chromatography , biochemistry , in vitro , hormone , enzyme , polysaccharide , rna , materials science , metallurgy , gene
The production of diethylstilbestrol monoglucuronide – (glucuronyl‐U‐ 14 C) by incubation of uridine diphospho‐D‐ glucuronic acid‐U‐ 14 C with diethylstilbestrol in the presence of guinea pig liver microsomes is described. The specific activity of the product was 9.1 mCi/mmole and the overall radiochemical yield was 13%, based on UDPGA – (glucuronyl‐U‐ 14 C).