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The synthesis of dimethoxymethyl phenobarbital labeled with 14 C
Author(s) -
Wang Theodore S. T.
Publication year - 1977
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580130416
Subject(s) - chemistry , phenobarbital , yield (engineering) , iodide , medicinal chemistry , radiochemistry , nuclear chemistry , stereochemistry , organic chemistry , pharmacology , thermodynamics , medicine , physics
Dimethoxymethyl phenobarbital (DMMP), labeled with 14 C on the ring and side chains was prepared for drug metabolism studies. The synthesis of DMMP‐ethyl‐1– 14 C (4a) in four steps provided a 43% yield from ethyl‐1– 14 C iodide. The yields of DMMP‐2– 14 C (4b) and DMMP‐dimethylene‐ 14 C (4c) were 87.5% and 30% respectively.