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Labelled compounds of potential biological interest. IV. Tritium labelling of some cyclzing compounds
Author(s) -
Gosztonyi Tamas,
Domeij Karl Erik,
Ross Svante
Publication year - 1977
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580130301
Subject(s) - chemistry , tritium , labelling , radiochemistry , ammonium , stereochemistry , organic chemistry , biochemistry , physics , nuclear physics
Quaternary ammonium compounds formed at the site of action by spontaneous cyclization of tertiary ω‐haloalkylamine precursors may have interesting pharmacological properties. In order to study the pharmacokinetics of the cyclization principle, a series of new tertiary ω‐haloalkylamines derived from p‐chloroamphetamine has been synthesized both unlabelled and labelled with tritium at high specific activity.