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The synthesis of two 14 C‐labelled hypoglycemic benzenesulphonylurea derivatives
Author(s) -
Elsom L. F.,
Hawkins D. R.,
Christensen H.,
Grønvald F. C.
Publication year - 1977
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580130107
Subject(s) - chemistry , carbonation , yield (engineering) , furan , carbon 14 , reagent , carboxylic acid , grignard reagent , organic chemistry , nuclear chemistry , medicinal chemistry , materials science , physics , quantum mechanics , metallurgy
The synthesis of two carbon‐14 labelled oral hypoglycemic benzo(b)furansulphonylureas is deseribed. The starting materials 2,3 ‐dihydrobenzo (b)furan ‐7 ‐carboxylic acid and 5 methyl–2, 3‐dihydrobenzo (b)furan‐7‐ 14 C‐carboxylic acid were prepared in high yield by carbonation of appropriate Grignard reagents. The final products were obtained with specific activities of 49 and 44 mCi/mmole and radiochemical purities of greater than 99%.