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The preparation of [ 14 C]‐labelled 16‐aryloxy prostaglandin f2α analogues. [I.C.I. 81,008 and I.C.I. 80,996]
Author(s) -
White D. F.
Publication year - 1977
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580130103
Subject(s) - chemistry , acetic acid , potassium cyanide , potassium , cyanide , medicinal chemistry , stereochemistry , organic chemistry
The preparations of [ 14 C]‐labelled racemic (95,11R,15R)‐9, 11,15‐trihydroxy‐16‐(3‐trifluoromethylphenoxy)‐17,18,19,20‐tetranor‐5‐ cis ,13‐ trans ‐prostadienoic acid [I.C.I. 81,008] from chloro[1‐ 14 C]acetic acid and potassium[ 14 C]cyanide, and [ 14 C]‐labelled racemic (95,11R,15R)‐16‐(3‐chlorophenoxy)‐9,11,15‐trihydroxy‐17,18,19,20‐tetranor‐5‐ cis ,13‐ trans ‐prostadienoic acid [I.C.I. 80,996] from chloro[1‐ 14 C]acetic acid and potassium[ 14 C] cyanide are described.