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Preparation de l'acide biphenyl‐4, oxo‐4, methylene‐2 butyrique ( 14 C‐4) et de deux derives chloro substitues
Author(s) -
Cousse Henri,
Bonnaud Bernard,
Pichat Louis,
Aubert Francis
Publication year - 1976
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580120403
Subject(s) - chemistry , itaconic acid , methylene , hydrolysis , biphenyl , acrylate , medicinal chemistry , sodium cyanide , organic chemistry , cyanide , monomer , copolymer , polymer
Itaconic acid‐4‐ 14 C has been prepared by condensation of sodium cyanide 14 C with ethyl α‐bromomethyl acrylate and hydrolysis of the intermediate ethyl α‐(cyanomethyl) acrylate. Itaconic anhydride‐4‐ 14 C has been used in Friedel‐Crafts reactions with respectively biphenyl, 2‐chlorobiphenyl, 4‐chlorobiphenyl for the preparation of 4‐biphenyl‐4‐oxo‐2‐methylene butyric acid‐4‐ 14 C and the corresponding‐2′chloro and 4′‐chloro substituted derivatives.