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Synthesis of 14 C‐labelled 2,4,‐diamino‐5‐phenylthiazole hydrochloride (amiphenazole)
Author(s) -
Adams Jeffrey G.,
Nicholls Paul J.,
Williams Hywel
Publication year - 1976
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580120211
Subject(s) - chemistry , hydrochloride , carbon 14 , medicinal chemistry , stereochemistry , organic chemistry , quantum mechanics , physics
The synthesis of 2,4‐diamino‐5‐phenylthiazole hydrochloride labelled with carbon – 14 in the 2‐position has been effected whereby the 14 C‐label was introduced in the last step. The overall yields were 34.5% (gravimetrically) and 32.8% (radiochemically).