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A high yield synthesis of C‐14‐ ring‐labeled and C‐14‐ methyl‐labeled N‐methyl‐N‐nitrosoaniline
Author(s) -
Grandjean C. J.
Publication year - 1976
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580120207
Subject(s) - chemistry , yield (engineering) , methyl iodide , aniline , ring (chemistry) , radiochemistry , medicinal chemistry , organic chemistry , materials science , metallurgy
Abstract A synthetic procedure for C‐14‐labeled N‐methyl‐N‐nitrosoaniline is presented. Separate labeling of the methyl and phenyl side chains was achieved by using C‐14‐labeled methyl iodide and aniline, respectively. The overall yield of the four reactions was 62% and the final products were stable as stored and chemically and radiochemically pure.