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Synthesis of 4‐thia[5‐ 13 C]lysine
Author(s) -
Maity Amarendra Nath,
Ke ShyueChu
Publication year - 2011
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1893
Subject(s) - chemistry , hydrobromide , lysine , ethylamine , hydrochloride , isotopomers , chemical synthesis , cysteine , stereochemistry , amino acid , medicinal chemistry , organic chemistry , in vitro , molecule , biochemistry , enzyme
This report describes the synthesis of 4‐thia[5‐ 13 C]lysine, an isotopomer of 4‐thialysine that is an analog of lysine. It was synthesized from 2‐amino[1‐ 13 C]ethanol hydrochloride (1) in two steps. In the first step, 1 was converted to 2‐bromo[2‐ 13 C]ethylamine hydrobromide (2). The reaction of cysteine with 2 in basic condition followed by acidification afforded 4‐thia[5‐ 13 C]lysine hydrochloride (3).