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Quantitative proteomic analyses in blood: A window to human health and disease
Author(s) -
Whittaker Kelly,
Burgess Rob,
Jones Valerie,
Yang Yanqing,
Zhou Weifan,
Luo Shuhong,
Wilson Jarad,
Huang RuoPan
Publication year - 2019
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.mr1118-440r
Subject(s) - biology , disease , computational biology , human health , immunology , environmental health , pathology , medicine
Abstract This review discusses how the measurement of proteins in blood and its components via quantitative proteomics analyses can inform health status. Various external and internal factors such as environmental conditions, genetic background, nutrition, diet, and lifestyle, chronic pathological conditions, disease state, or therapeutic intervention will be investigated and their effects on the protein profile will be shown. The resulting changes to ones’ health and how this protein expression information can be used in early screening/diagnostic applications, drug discovery, precision treatment, patient management, and monitoring overall health status will also be presented.