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Advances on the role of the deleted in breast cancer (DBC1) in cancer and autoimmune diseases
Author(s) -
Fang Qiannan,
Bellanti Joseph A.,
Zheng Song Guo
Publication year - 2021
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.6mr0320-086r
Subject(s) - biology , cancer , breast cancer , epigenetics , cancer research , immunology , function (biology) , bioinformatics , genetics , gene
Abstract DBC1 (deleted in breast cancer 1) is a human nuclear protein that modulates the activities of various proteins. Most of the research on DBC1 has focused on metabolism and epigenetics because it is a crucial endogenic inhibitor of deacetylase Sirtuin1 (SIRT1). In this review, we have discussed and summarized the new advances in DBC1 research, mostly focusing on its structure, regulatory function, and significance in cancer and autoimmune diseases.