Premium
The Synthesis of the Principal Dihydroisocoumarins of Ononis natrix
Author(s) -
Rama Nasim H.,
Saeed Aamer,
Bird Clive W.
Publication year - 1993
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1993199301217
Subject(s) - natrix , chemistry , acetic acid , enantiomer , stereochemistry , organic chemistry , biology , ecology
(±)‐6,8‐Dihydroxy‐3‐undecyl‐3,4‐dihydroisocoumarin ( 7 ) and its 6‐ O ‐methyl and 6,8‐di‐ O ‐methyl derivatives 6 and 5 , isolated as the (−)‐enantiomers from the plant Ononis natrix by other authors, were synthesized starting with (3,5‐dimethoxyphenyl)acetic acid via (±)‐1‐(3,5‐dimethoxyphenyl)tridecan‐2‐yl acetate ( 2 ) and its corresponding 2‐formyl and 2‐carboxy derivatives 3 and 4 , respectively.