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Antibiotika aus Gleitenden Bakterien, LV – Myxochromid A: Ein hochungesättigtes Lipopeptidlacton aus Myxococcus virescens
Author(s) -
TrowitzschKienast Wolfram,
Gerth Klaus,
Wray Victor,
Reichenbach Hans,
Höfle Gerhard
Publication year - 1993
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1993199301200
Subject(s) - chemistry , moiety , stereochemistry , amide , chromophore , residue (chemistry) , pigment , lactone , antibiotics , bacteria , biochemistry , organic chemistry , biology , genetics
Antibiotics From Gliding Bacteria, LV. – Myxochromide A: A Highly Unsaturated Lipopetide from Myxococcus virescens The isolation and structure elucidation of a new family of pigments, the myxochromides, are described. Myxochromide A was determined as a hexapeptide lactone out of: L ‐Methyl‐Thr, D ‐ or L ‐Ala, L ‐Leu, L ‐Pro, D ‐ or L ‐Ala and L ‐Glu, respectively. Its lactone formation was observed between the γ‐carboxyl of Glu and the OH group of the Me‐Thr residue. The chromophore, a heptaenoic acid, was found to bind as an amide to the N‐atom of the Thr moiety. Myxococcus flavescens produces the same pigments with myxochromide B as the main compounds.