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Studies on Isocyanides and Related Compounds. A Facile Synthesis of Imidazo[1,5‐ a ]imidazoles
Author(s) -
Bossio Ricardo,
Marcaccini Stefano,
Pepino Roberto
Publication year - 1993
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1993199301199
Subject(s) - chemistry , potassium thiocyanate , imidazole , condensation , isocyanide , thiocyanate , amine gas treating , combinatorial chemistry , component (thermodynamics) , potassium , organic chemistry , medicinal chemistry , thermodynamics , physics
The Ugi four‐component condensation between 1,1‐diethoxy‐2‐isocyanoethane ( 2 ), cycloketones 1 , amine hydrochlorides 4 , and potassium thiocyanate ( 3a ) or selenocyanate ( 3b ) affords spiroimidazoles 5 , which are cyclized to spiroimidazo[1,5‐ a ]imidazole‐5‐thiones (or selenones) 6 .