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Diterpenoid Total Synthesis, XXX. Synthesis of the Racemic Form of Tripterifordin, a Novel Anti‐HIV Diterpene Lactone from Tripterygium wilfordii
Author(s) -
Mori Kenji,
Aki Shinji
Publication year - 1993
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199319930116
Subject(s) - diterpene , tripterygium wilfordii , chemistry , lactone , stereochemistry , ketone , terpenoid , tripterygium , abietane , total synthesis , organic chemistry , glycoside , medicine , alternative medicine , pathology
The pentacyclic diterpene ketone (±)‐ 3 , which had been prepared by a total synthesis from naphthalene, was methylenated and hydrated to give (±)‐tripterifordin [(±)‐ 1 ], the racemate of a new kaurane‐type diterpene lactone with anti‐HIV activity recently isolated from the roots of Tripterygium wilfordii .