Premium
Synthesen von α‐Aminophosphonsäuren aus N ‐Ethoxyiminium‐Salzen, II
Author(s) -
Shatzmiller Shimon,
Neidlein Richard,
Weik Christian
Publication year - 1993
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1993199301152
Subject(s) - chemistry , hydrogenolysis , hydrolysis , amino acid , organic chemistry , medicinal chemistry , catalysis , biochemistry
Syntheses of α‐Aminophosphonic Acids from N ‐Ethoxyiminium Salts, II Nitrones 2 obtained from aldehydes 1 are used for the synthesis of N ‐ethoxyiminium salts 3 . These react with several esters of hydrogen phosphite 4 to give the N ‐methyl α‐amino phosphonic esters 5 to 13 . The N ‐benzyl α‐amino phosphonic esters 24 and 25 can be obtained by the same procedure. Hydrogenolysis and ester hydrolysis afford the α‐amino phosphonic acids 14 as well as 26 and 27 , respectively.