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Totalsynthese von Thymosin β 4 , 1. Klassische Synthese des Fragments [11–19] von Thymosin β 4
Author(s) -
Kapurniotu Afroditi,
Voelter Wolfgang
Publication year - 1991
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1991199101216
Subject(s) - thymosin , chemistry , total synthesis , fragment (logic) , stereochemistry , peptide fragment , biochemistry , peptide , computer science , programming language
Total Synthesis of Thymosin β 4 , 1. – Conventional Synthesis of the Fragment [11–19] of Thymosin β 4 As part of the total synthesis of thymosin β 4 two synthetic pathways for the synthesis of the thymosin β 4 fragment [11–19] are described. The side‐chain functions are protected by tert ‐butyl and the α‐amino residues by Z groups. As temporary protection of the carboxyl function the phenyl ester is successfully used.