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Synthesis of 10,11‐dihydroxyaporphines and of protected 10,11‐dihydroxyaporphines from codeine
Author(s) -
Ram Vishnu J.
Publication year - 1988
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198819881112
Subject(s) - methylenedioxy , chemistry , thionyl chloride , codeine , chloride , medicinal chemistry , stereochemistry , organic chemistry , pharmacology , morphine , medicine , alkyl , halogen
Abstract N ‐Alkylnoraporphines 6 and their 10,11‐(methylenedioxy) derivatives 5 are prepared from codeine ( 1 ). Furthermore, the nitrogen mustard 7 is prepared from N ‐(2‐hydroxyethyl)‐10,11‐(methylenedioxy)noraporphine ( 5e ) by reaction with thionyl chloride.