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Pteridine analogues; synthesis and physico‐chemical properties of 7‐oxopyrazino[2,3‐ c ][1,2,6]thiadiazine 2,2‐dioxides
Author(s) -
Goya Pilar,
Páez Juan Antonio
Publication year - 1988
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198819880204
Subject(s) - chemistry , yield (engineering) , pteridine , condensation , chemical shift , stereochemistry , nmr spectra database , organic chemistry , combinatorial chemistry , spectral line , materials science , physics , astronomy , metallurgy , thermodynamics , enzyme
Condensation of diaminothiadiazine 1,1‐dioxides 1 or 8 with α‐keto acid esters affords 7‐oxopyrazino[2,3‐ c ][1,2,6]thiadiazine 2,2‐dioxides 2–4 and 9 . Further chemical transformations yield 6‐substituted derivatives. The structures of the newly synthesized compounds are discussed on the basis of 1 H‐ and 13 C‐NMR data, UV spectra and p K α values.