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Verbesserte Synthese von 6β, 7β‐Epoxy‐17β‐hydroxy‐3‐oxo‐4,6‐pregnadien‐21‐carbonsäure‐γ‐lacton
Author(s) -
Reinholz Erhard,
Vogler Fritz
Publication year - 1987
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198719870865
Subject(s) - chemistry , metabolite , epoxy , yield (engineering) , derivative (finance) , stereochemistry , lactone , organic chemistry , biochemistry , materials science , economics , financial economics , metallurgy
Improved Synthesis of 6β, 7β‐Epoxy‐17β‐hydroxy‐3‐oxo‐4,6‐pregnadiene‐21‐carboxylic Acid γ‐Lactone The title compound 2 , a metabolite of canrenone ( 1 ) in rats, is synthesized starting from 1 via derivative 3c in a 25‐g scale in a much shorter time and higher yield than in the literature cited.