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Annulated 1,2,3‐triazoles, I. Synthesis of 8‐Azapurin‐6‐ones and 8‐Azapurin‐6‐imines from Ethyl 5‐Acetylamino‐1,2,3‐triazole‐4‐carboxylates
Author(s) -
Nielsen Flemming E.,
Pedersen Erik B.,
Begtrup Mikael
Publication year - 1984
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198419841109
Subject(s) - chemistry , phosphorus pentoxide , triazole , amine gas treating , organic chemistry , medicinal chemistry , 1,2,4 triazole , combinatorial chemistry
The new 8‐azapurin‐6‐ones 3 and the corresponding 8‐azapurin‐6‐imines 4 are prepared by cyclocondensation of ethyl 5‐acetylamino‐1 H ‐1,2,3‐triazole‐4‐carboxylates 2 with amine hydrochlorides in the presence of phosphorus pentoxide and N , N ‐dimethylcyclohexylamine. A reaction pathway is proposed for the formation of 3 and 4 . Various products 3 have been tested for fungicide activity.