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Synthesis of 2‐aminoquinazolinc‐4(3 H )‐one derivatives as potential potassium channel openers
Author(s) -
Erb BÉNÉDicte,
Akue Rufine,
Rigo Benoît,
Pirotte Bernard,
Couturier Daniel
Publication year - 2000
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570370206
Subject(s) - chemistry , diazoxide , pinacidil , potassium channel , potassium channel opener , potassium , benzopyrans , cromakalim , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , biophysics , receptor , medicine , agonist , biology , glibenclamide , insulin , diabetes mellitus , endocrinology
Abstract Starting from 2‐thioxoquinazolin‐4‐one, the synthesis of 2‐amino‐4(3 H )‐one derivatives, structurally related to potassium channels openers pinacidil and diazoxide, is described.