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2,2‐Dioxo‐1 H ‐thieno[3,4‐ c ][1,2]thiazines. Synthesis and some reactions of a new heterocycle
Author(s) -
Fanghänel Egon,
Bartossek Hagen,
Baumeister Ute,
Biedermann Matthias,
Hartung Helmut
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350639
Subject(s) - chemistry , formylation , dimethylformamide , thiazine , amine gas treating , sulfur , medicinal chemistry , organic chemistry , catalysis , solvent
The first synthesis of substituted 2,2‐dioxo‐1‐phenyl‐1 H ‐thieno[3,4‐ c ][1,2]thiazines 2 and some of their reactions are achieved. Compounds 2 were prepared from the 3,5‐dimethyl‐1,1‐dioxo‐1,2‐thiazine‐4‐carbaldehydes 1 by reaction with sulfur and triethyl amine in dimethylformamide under mild conditions. They were characterized spectroscopically and by X‐ray structure analysis. The formylation, chlorination and oxidation of 2 are reported.