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Synthesis of new 6‐(4‐chlorophenyl)perhydro‐1,3‐diazepine‐2,4‐diones via ureidobutyric acids
Author(s) -
Guillon Jean,
Sonnet Pascal,
Dallemagne Patrick,
Miel Hugues,
Rault Sylvain,
Daoust Martine,
Boulouard Michel
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350308
Subject(s) - chemistry , diazepine , butyric acid , ring (chemistry) , stereochemistry , organic chemistry
Abstract Synthesis of new 6‐(4‐chlorophenyl)perhydro‐1,3‐diazepine‐2,4‐diones was accomplished starting from 4‐amino‐3‐(4‐chlorophenyl)butyric acid (Baclofen). The chemical pathway involved the cyclisation of various 3‐(4‐chlorophenyl)‐4‐ureidobutyric acids. However, none of the new derivatives retained the anticonvulsant activity of their six‐membered ring homologues, belonging to the phenylpyrimidinedione series which we recently described.