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1,2,4‐Triazoles. Improved synthesis of 5‐substituted 4‐amino‐3‐mer‐cato‐(4 H )‐1,2,4‐triazoles and a facile route to 3,6‐disubstituted 1,2,4‐triazolo[3,4‐ b ][1,3,4]thiadiazoles
Author(s) -
Invidiata Francesco Paolo,
Furná Giancarlo,
Lampronti Ilaria,
Simoni Daniele
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340427
Subject(s) - chemistry , ring (chemistry) , triazole , amino acid , 1,2,4 triazole , carboxylic acid , combinatorial chemistry , reaction conditions , organic chemistry , catalysis , biochemistry
Abstract The reaction of thiocarbohydrazide with carboxylic acids at the melting temperature allows an improved preparation of the S‐substituted 4‐amino‐3‐mercapto‐1,2,4‐triazole heterocycles. The crude 4‐amino‐5‐mercapto‐1,2,4‐triazoles react easily with carboxylic acids or carboxylic acid chlorides to afford the 1,2,4‐triazolo[3,4‐ fc ][1,3,4]thiadiazole ring system.