Synthesis and anticonvulsant activity of 2‐aryl‐3,4‐dialkyltetrahydro‐1,3,4‐oxadiazines and 2‐aryl‐3,4‐dialkyltetrahydro‐1,3,4‐oxadiazin‐5‐ones | Zendy

Kornet Milton J. | Zendy

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Synthesis and anticonvulsant activity of 2‐aryl‐3,4‐dialkyltetrahydro‐1,3,4‐oxadiazines and 2‐aryl‐3,4‐dialkyltetrahydro‐1,3,4‐oxadiazin‐5‐ones

Author(s) -

Kornet Milton J.

Publication year - 1996

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570330679

Subject(s) - chemistry , aryl , anticonvulsant , ethanol , medicinal chemistry , organic chemistry , epilepsy , alkyl , neuroscience , biology

Several 2‐aryl‐3,4‐dialkyltetrahydro‐1,3,4‐oxadiazines have been synthesized from 2‐(1,2‐dialkylhydrazino)ethanol (2) and aromatic aldehydes. Also, three 2‐aryl‐3,4‐dialkyltetrahydro‐1,3,4‐oxadiazin‐5‐ones were obtained from the reaction of 1,2‐dialkylglycolylhydrazine (5) and aromatic aldehydes. These compounds exhibited activity in the maximal electroshock seizure test.

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