Premium
NMR spectra and conformational analysis of some 4,5‐dihydro‐ s ‐triazolo[3,4‐ d ][1,5]benzothiazepine derivatives
Author(s) -
Ambrogi Valeria,
Grandolini Giuliano,
Perioli Luana,
KajtàrPeredy Maria,
Radics Lajos
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310609
Subject(s) - chemistry , conformational isomerism , substituent , ring (chemistry) , nmr spectra database , stereochemistry , molecule , spectral line , proton nmr , crystallography , organic chemistry , physics , astronomy
Abstract High field 1 H and 13 C nmr spectra of a series of 1‐substituted‐4,5‐dihydro‐ s ‐triazolo[3,4‐ d ][1,5]benzothiazepine derivatives have been recorded. These have shown that, unless X = H or O, the molecules occur as a mixture of two slowly interconverting conformers at ambient temperatures. Variable temperature nmr experiments disclosed that the energy barrier to interconversion varies with the size of the substituent X located at position 1 of the fused s ‐triazole ring.