Premium
A facile synthesis of 3‐aryl‐4‐pyrazoleacetic acids and of their 4,5‐dihydro derivatives
Author(s) -
Curzu Maria M.,
Pinna Gérard A.,
Barlocco Daniela,
Cignarella Giorgio
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270217
Subject(s) - chemistry , hydrazine (antidepressant) , acetic acid , hydrate , bromine , aryl , organic chemistry , chromatography , alkyl
N ‐1‐Unsubstituted‐3‐aryl‐4‐pyrazoleacetic acids and their 4,5‐dihydro derivatives can conveniently be prepared by cyclization of 3‐benzoyl‐3‐butenoic acids with hydrazine hydrate in acetic acid and subsequent treatment with bromine in acetic acid or, respectively, with diluted mineral acids.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom