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An improved synthesis of galanthamine
Author(s) -
Szewczyk Jerzy,
Lewin Anita H.,
Carroll F. I.
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250639
Subject(s) - chemistry , yield (engineering) , sequence (biology) , alkaloid , tyramine , organic chemistry , stereochemistry , biochemistry , materials science , metallurgy
Abstract Modifications in the total synthesis of the Amarylidaceae alkaloid of galanthamine from commercially available isovanillin and tyramine have resulted in a shortened reaction sequence, which is amenable to upscaling and in improved product yield.