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The synthesis of benzofuroquinolines. III. Two dihydroxybenzofuroquinolinones
Author(s) -
Yamaguchi Seiji,
Yoshimoto Yoshiteru,
Murai Rikuko,
Masuda Fumihiko,
Yamada Minora,
Kawase Yoshiyuki
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210320
Subject(s) - chemistry , diazomethane , stereochemistry , medicinal chemistry , methylation , biochemistry , gene
Two dihydroxybenzofuroquinolinones, 3,9‐dihydroxy‐5 H ‐benzofuro[3,2‐ c ]quinolin‐6‐one (V) and 3,8‐dihydroxy‐6 H ‐benzofuro[2,3‐ b ]quinolin‐11‐one (VI), were obtained by the demethyl‐cyclization of 3‐(2,4‐dimethoxyphenyl)‐4‐hydroxy‐7‐methoxy‐1 H ‐quinolin‐2‐one (IV). By the methylation with diazomethane, V gave a dimethylated compound (VII), while VI gave a trimethylated compound (VIII).
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