Premium
4‐Azapteridines. I. Covalent addition products of the pyrazino[2,3‐ e ]‐ as ‐triazine ring system
Author(s) -
Tzeng Cherng Chyi,
Panzica Raymond P.
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200458
Subject(s) - chemistry , glyoxal , triazine , ring (chemistry) , methanol , medicinal chemistry , covalent bond , stereochemistry , polymer chemistry , organic chemistry
Abstract Ring closure of 5, 6‐diamino‐3‐methylthio‐ as ‐triazine with 40% aqueous glyoxal provided the 6, 7‐dihydrate of the pyrazino[2, 3‐ e ]‐ as ‐triazine (4‐azapteridine) ring system. The C7 hydroxy group of this dihydrate underwent exchange in methanol or ethanol affording the 7‐alkoxy, 6‐hydroxy derivatives.