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Attempted synthesis of 2,4‐ and 1,3‐benzodiazepinones
Author(s) -
Golik Uri,
Taub William
Publication year - 1975
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570120613
Subject(s) - chemistry , triazine , combinatorial chemistry , stereochemistry , organic chemistry
The cyclodehydration reaction performed upon α‐acylamino carboxamides is known to constitute a facile synthetic approach to five‐membered heterocyclic systems. Attempts to prepare 2,4‐ and 1,3‐benzodiazepinone derivatives (VI, XIX) of potential C.N.S. Activity using such methods, proved unsuccessful. A new triazine system (X) which was prepared did not exhibit any C.N.S. activity.
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