Premium
Microwave Assisted Neat Synthesis of Spiropyrrolidine Library
Author(s) -
Kalluraya Balakrishna,
Mallya Sahana,
Kumar K Anish
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3247
Subject(s) - chemistry , regioselectivity , cycloaddition , microwave , combinatorial chemistry , solvent , organic chemistry , catalysis , physics , quantum mechanics
A new class of functionalized nitrothiophene containing spirropyrrolidines has been synthesized with high regioselectivity in moderate to excellent yields via microwave assisted solvent‐free‐three component 1,3‐dipolar cycloaddition reaction of in situ generated azomethineylides with various substituted chalcones as dipolarophiles. The structures of the newly synthesized compounds were established by analytical and spectral analysis. The product yields were slightly improved and reaction times were reduced to a great extent under microwave condition.