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A Convenient and Efficient Approach for the Synthesis of New 2‐ N ‐substituted 2,5‐dihydrofuran‐3‐carboxamides
Author(s) -
Tokmajyan Gayane,
Karapetyan Lusine
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2713
Subject(s) - chemistry , acetic acid , sulfanilamide , environmentally friendly , combinatorial chemistry , organic chemistry , biochemistry , ecology , biology
In order to obtain potent biological active compounds, a convenient and efficient method for the synthesis of compounds comprising 2‐imino‐2,5‐dihydrofuran, aromatic, sulfamoyl, and heterocyclic fragments has been presented. This environmentally friendly method was based on the reaction of 2‐imino‐2,5‐dihydrofuran‐3‐carboxamides with analgesic and sulfanilamide drugs and 4‐aminoantipyrine in glacial acetic acid and afforded high yields of the products.

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