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Polycyclic N ‐Heterocyclic Compounds. Part 85: Synthesis and Evaluation of Antiplatelet Aggregation Activity of 2,4‐Disubstituted 5,6‐Dihydro[1]benzazepino[5,4‐ d ]pyrimidine and Related Compounds
Author(s) -
Okuda Kensuke,
Zhang YingXue,
Hirota, Takashi,
Sasaki Kenji
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2040
Subject(s) - chemistry , pyrimidine , aryl , tricyclic , platelet aggregation , alkyl , aspirin , stereochemistry , combinatorial chemistry , platelet , organic chemistry , biochemistry , immunology , biology
We have synthesized a large number of tricyclic 2‐substituted 4‐alkylamino‐5,6‐dihydro[1]benzazepino[5,4‐ d ]pyrimidines as part of our research to develop new effective antiplatelet drugs. A variety of alkyl and aryl groups were used as substituents at the 2‐position. Evaluation of the effects of the newly synthesized compounds on collagen‐induced platelet aggregation revealed several promising antiplatelet candidates with potencies superior to aspirin.
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