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Long‐term efficacy and safety of programmed death‐1 (PD‐1) antibody alone in relapsed/refractory human immunodeficiency virus‐associated Hodgkin lymphoma
Author(s) -
Wang Chaoyu,
Zhou Fanlin,
Zhang Lingqian,
Liu Tingting,
Nan Yingyu,
Liu Yao
Publication year - 2022
Publication title -
ejhaem
Language(s) - English
Resource type - Journals
ISSN - 2688-6146
DOI - 10.1002/jha2.448
Subject(s) - abvd , medicine , lymphoma , refractory (planetary science) , regimen , chemotherapy , disease , human immunodeficiency virus (hiv) , immunodeficiency , antibody , oncology , immunology , cyclophosphamide , immune system , vincristine , physics , astrobiology
We report a young patient initially diagnosed with human immunodeficiency virus (HIV)‐associated Hodgkin lymphoma (HL), and received six cycles of ABVD chemotherapy regimens and involvement field irradiation therapy. However, the disease progressed after two months later, and then received second line GDP regimen. Unfortunately, after five cycles of GDP, the patient progression disease (PD) again. The patient was then offered sintilimab alone. After 8 cycles, the patient received complete response (CR) and no 3/4 grade toxicity. Currently, at a follow‐up period of four years, he is still alive with CR and no lymphoma‐related symptoms. This case demonstrates the feasibility of sintilimab antibody in relapsed/refractory HIV‐associated Hodgkin lymphoma.

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