Premium
Impact of hyperoxia on cardiac pathophysiology
Author(s) -
Rodgers Jennifer L.,
Iyer Drishya,
Rodgers Lydia E.,
Vanthenapalli Sahit,
Panguluri Siva K.
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28136
Subject(s) - hyperoxia , medicine , pathophysiology , hypoxia (environmental) , cardiac output , intensive care medicine , ventilation (architecture) , stroke volume , cardiology , lung , anesthesia , hemodynamics , oxygen , heart rate , blood pressure , mechanical engineering , chemistry , organic chemistry , engineering
Abstract Mechanical ventilation with high oxygen therapy (hyperoxia) is widely implemented in critical care and ICU settings. Although supplemental oxygen is beneficial to treat hypoxia, its use is also associated with poor outcomes and high mortality in patients. Lung injury due to hyperoxia exposure has been well‐documented in patients, including in adults and neonates. Thus, lung injury due to hyperoxia has been extensively researched in both preclinical and clinical studies. However, hyperoxia has also been shown to be associated with hemodynamic changes in patients in ICU, including reductions in heart rate, stroke volume, and cardiac output. In addition, certain experimental studies report that hyperoxia exposure in neonates results in cardiac dysfunction in later adult life. Despite this, until recently, the impact of hyperoxia within the heart has not been well studied, or reported, specifically in adult experimental models. To close this significant gap, our lab has sought to clarify hyperoxia‐induced cardiac pathophysiology in adult murine models. This review discusses the current findings regarding the cardiovascular impact of hyperoxia exposure.