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Synergistic anticancer action of quercetin and curcumin against triple‐negative breast cancer cell lines
Author(s) -
Kundur Sai,
Prayag Amrita,
Selvakumar Priyanga,
Nguyen Hung,
McKee Lloyd,
Cruz Clairissa,
Srinivasan Asha,
Shoyele Sunday,
Lakshmikuttyamma Ashakumary
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27761
Subject(s) - curcumin , cancer research , gene knockdown , triple negative breast cancer , quercetin , cell culture , breast cancer , cell , acetylation , cancer cell , cancer , suppressor , chemistry , biology , pharmacology , medicine , gene , biochemistry , genetics , antioxidant
Abstract Women with the breast cancer type 1 susceptibility protein (BRCA1) mutation and loss of BRCA1 expression are reported to have an increased risk of triple‐negative breast cancer (TNBC). Targeting BRCA1 modulation might offer a therapeutic option to treat TNBC patients. Our studies detected that BRCA1 is poorly expressed in TNBC cell lines and highly expressed in ER + breast cancer cell lines. To modulate BRCA1 expression, we tested two different dietary components to find out if any would induce tumor suppressor genes. We detected that quercetin and curcumin dose‐dependently enhanced the BRCA1 expression. Further, a synergistic action of quercetin and curcumin was observed in modulating the BRCA1 level and in inhibiting the cell survival and migration of TNBC cell lines. Quercetin and curcumin appeared to induce BRCA1 promoter histone acetylation. Furthermore, BRCA1 knockdown induced cell survival and cell migration in ER + cells were significantly decreased by the combined treatment of quercetin and curcumin. Our present study concluded that the combination treatment of quercetin and curcumin acts synergistically to induce anticancer activity against TNBC cells by modulating tumor suppressor genes.