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Signaling pathways in medulloblastoma
Author(s) -
Guessous Fadila,
Li Yunqing,
Abounader Roger
Publication year - 2008
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.21542
Subject(s) - medulloblastoma , wnt signaling pathway , biology , receptor tyrosine kinase , hedgehog , cancer research , malignancy , signal transduction , sonic hedgehog , neuroscience , bioinformatics , microbiology and biotechnology , genetics
Abstract Medulloblastoma is the most common brain tumor of childhood. Multiple signaling pathways have been associated with medulloblastoma formation and growth. These include the developmental pathways Hedgehog, (Hh) Notch, and Wnt as well as the receptor tyrosine kinases (RTK) c‐Met, erbB2, IGF‐R and TrkC, and the oncoprotein Myc. Here we review the involvement of these pathways in medulloblastoma malignancy with a focus on their mode of deregulation, prognostic value, functional effects, cellular and molecular mechanisms of action, and implications for therapy. J. Cell. Physiol. 217: 577–583, 2008. © 2008 Wiley‐Liss, Inc.