Open AccessPossible effects of Treponema pallidum infection on human vascular endothelial cells
Author(s) -
Xie Bibo,
Zhao Tie,
Zhao Sisi,
Zhou Jie,
Zhao Feijun
Publication year - 2022
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.24318
Subject(s) - treponema , endothelium , secretion , immune system , biology , host (biology) , microbiology and biotechnology , immunology , syphilis , human immunodeficiency virus (hiv) , endocrinology , ecology
Abstract Pathogens can affect host cells in various ways, and the same effect can be found in the Treponema pallidum acting on the endothelium of host vessels, and the mechanism is often complex and multiple. Based on the existing T. pallidum of a cognitive framework, the first concerns involving T. pallidum or the bacteria protein directly acted on vascular endothelial cells of the host, the second concerns mainly involved in the process of T. pallidum infection in vivo blood lipid change, secretion of cytokines and the interactions between immune cells indirectly. Through both direct and indirect influence, this study explores the role of host by T. pallidum infect in the process of the vascular endothelium.