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The frequency of bone marrow cells that bind erythropoietin
Author(s) -
Weiss Tania L.,
Kung Charles K. H.,
Goldwasser Eugene,
Meier Paul
Publication year - 1985
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240270107
Subject(s) - erythropoietin , bone marrow , immunofluorescence , in vitro , erythropoiesis , function (biology) , chemistry , microbiology and biotechnology , biology , immunology , medicine , endocrinology , anemia , biochemistry , antibody
Abstract The frequencies of rat and mouse bone marrow cells capable of binding erythropoietin were studied by both direct fluorescence and indirect immunofluorescence. We found that between 1–2% of the cells bound erythropoietin, that the binding was specific, and that the number of cells that bound erythropoietin was in part, a function of the erythropoietic state of the donor animal. A statistical method for evaluating the data obtained is included.