Premium
Conditions for obtaining polyvinyl alcohol/trisodium trimetaphosphate hydrogels as vitreous humor substitute
Author(s) -
MorandimGiannetti Andreia de Araujo,
Silva Rosianne Cristina,
Magalhães Octaviano,
Schor Paulo,
Bersanetti Patrícia Alessandra
Publication year - 2016
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33473
Subject(s) - self healing hydrogels , polyvinyl alcohol , materials science , swelling , fourier transform infrared spectroscopy , polymer chemistry , chemical engineering , attenuated total reflection , context (archaeology) , composite material , paleontology , engineering , biology
Abstract Hydrogels are polymeric materials with numerous medical and biological applications because of their physicochemical properties. In this context, the conditions were defined for obtaining a hydrogel with characteristics similar to the vitreous humor using polyvinyl alcohol (PVA) and trisodium trimetaphosphate (STMP). The concentration of PVA ( X 1 ), PVA/STMP ratio ( X 2 ), and initial pH ( X 3 ) were modified, and their effect was analyzed in terms of the refractive index ( Y 1 ), density ( Y 2 ), dynamic viscosity ( Y 3 ), and final pH ( Y 4 ). The results demonstrated that X 1 interferes with Y 1 , Y 2 , and Y 3 , and X 2 interferes with Y 2 and Y 3 . The best condition for obtaining a hydrogel with characteristics similar to the vitreous humor was 4.2586% PVA (wt/wt), STMP/PVA ratio of 1:6.8213 (wt/wt), and initial pH of 9.424. DSC, ATR‐FTIR, swelling degree, and AFM analysis confirmed the PVA reticulation with STMP. Furthermore, STMP increased the glass transition temperature and decreased the water uptake of ∼50% of the hydrogels, which can be explained by the crosslinking of PVA chains. Infrared spectroscopy revealed a decrease of hydroxyl bonds and confirmed the reticulation between PVA and STMP. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1386–1395, 2016.